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* Vardenafil (Buy Levitra *)Russian title:
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Features:
Selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5).
Hydrochloride Vardenafil - almost as a colorless solid having a molecular weight of 579.1, and the water solubility of 0.11 mg / ml.
Application:
The treatment of erectile dysfunction.
Counter-arguments:
Hypersensitivity, concomitant use of nitrates or other drugs that are nitric oxide (PDE5 inhibitors may potentiate the hypotensive effects of nitrates, the corresponding interval of Buy Levitra and "later, nitrates, and nitric oxide is not defined) (see Pharmacology "- effect on blood pressure and heart accepted the amount of nitrate`), and alpha-blockers (development of hypotension).
The restrictions apply:
Buy Levitra is not intended for use by women, children and infants.
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Adverse reactions:
During the controlled and uncontrolled clinical studies of vardenafil hydrochloride throughout the world, more than 4430 men aged 18-89 years (mean age 56 years) of different racial and ethnic groups. More than 2200 patients to take medicine for six months or more, 880 patients - at least 1 year. In several placebo-controlled clinical trials, most patients who discontinued because of side effects of vardenafil was 3.4% versus 1.1% for placebo.
When you receive vardenafil hydrochloride with placebo in randomized controlled trials with fixed dose, and the use of different doses) was observed in the following side effects (see table). The table lists the adverse reactions were observed in patients with Buy Levitra 5 mg, 10 or 20 (for the adverse effects were observed for at least 2% of patients and greater than placebo). In studies with a variety of dishes, all patients initially received 10 mg of vardenafil, the dose was reduced to 5 mg or increased to 20 mg and tolerability.
Table
The side effects appear in placebo-controlled
Mechanism of Action
For the treatment of erectile dysfunction, phosphodiesterase type 5 (PDE5).
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Penile erection is a hemodynamic process based on the relaxation of arterial smooth muscle and placed in the corpora cavernosa. When sexual stimulation, is released from nerve endings in the corpora cavernosa nitric oxide (NO), activates the enzyme guanylate cyclase which results in increased corpus cavernosum of cyclic guanosine monophosphate (cGMP). The result is a relaxation of smooth muscle and corpus cavernosum, thereby increasing the flow of blood to the penis.
Vardenafil blocks PDE5, which is under the influence of the breakdown of cGMP, as a result of the activity of endogenous NO cavernosum during sexual stimulation to grow, with consequent possibility of vardenafil to improve the natural response to sexual stimulation.
The clinical effect is reached before the Cmax. Oral doses of 20 mg and 10 mg onset of action - within 10 minutes, which allows an erection sufficient and sexual intercourse is 34% and 40% of patients with mild to moderate erectile dysfunction, respectively. After 25 minutes, respectively, the effect is obvious from 53% to 50% of patients, which is the same as the initial one in the blood of active agent and a rapid increase of the concentration. Duration - 8-12 hours
